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The

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most com side effects of simvastatin are headache, nausea, chemist salary 2008 LDL cholesterol

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is believed to be an important cause of coronary artery disease. Decreased elimination of simvastatin could increase the levels of simvastatin in the body and increase the risk of muscle toxicity from simvastatin. The most serious potential side effects are liver damage and muscle inflammation or breakdown. It belongs to a class of drugs chemist warehouse locations called HMG-CoA reductase inhibitors, commonly called "statins." Other statins include lovastatin (Mevacor), atorvastatin (Lipitor), fluvastatin (Lescol), and

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rosuvastatin (Crestor). Large quantities of grape fruit juice

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( 1 quart daily) also will increase blood levels of simvastatin. In the blood, statins lower total and LDL ("bad") cholesterol as well as triglycerides. Printer-Friendly Format Email to a Friend From the Doctors at Statins - Explains Statin medications. Patients taking amiodarone or verapamil should not take more than 20 mg

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of simvastatin. Simvastatin should only be administered to women of child bearing age if they are not likely to become pregnant. Visit the FDA website or call 1-800-FDA-1088. Statins reduce cholesterol by inhibiting an enzyme in the liver (HMG-CoA reductase) that is necessary for the production of cholesterol. Oral disintegrating tablets should be stored

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between 20-25 C (68-77 F). Simvastatin increases the effect of warfarin (Coumadin) and the blood concentration of digoxin (Lanoxin). Therefore, simvastatin should only be taken 2 hours before or at least 4 hours after cholestyramine administration. The usual staring dose is 20-40 mg once daily. Patients taking

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danazol or cyclosporine should not take more than 10 mg of simvastatin.

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Amiodarone (Cordarone), verapamil (Calan Verelan, Isoptin), danazol (Danocrine), cyclosporine, niacin (Niacor, Niaspan, Slo-Niacin), gemfibrozil (Lopid) and fenofibrate (Tricor) also may increase the risk of muscle toxicity when combined with simvastatin. Simvastatin is used for reducing total cholesterol, LDL cholesterol, and triglycerides, and for increasing HDL cholesterol. The FDA approved simvastatin in December 1991. Cholestyramine (Questran, Questran Light) decreases the absorption

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of simvastatin. Simvastatin is prescribed for reducing the risk of mortality by reducing death from coronary heart disease, reducing nonfatal myocardial infarction (heart attack) and stroke, and reducing the need for coronary and noncoronary revascularization procedures. Hypersensitivity reactions have also been reported. Because of the risk of adverse effects to the developing infant, simvastatin should not be administered to nursing mothers. Patients taking

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simvastatin and warfarin or digoxin should be monitored carefully for toxic effects of warfarin and digoxin. Tablets should be stored between 5-30 C (41-86 F). Simvastatin is a cholesterol-lowering drug. Examples of drugs that decrease elimination of simvastatin include erythromycin (E-Mycin), ketoconazole (Nizoral), itraconazole (Sporanox), clarithromycin (Biaxin), telithromycin (Ketek), cyclosporine (Sandimmune), nefazodone (Serzone), and HIV protease inhibitors such as indinavir (Crixivan) and ritonavir (Norvir). In patients with coronary heart disease, diabetes, peripheral vessel disease, or history of stroke or other cerebrovascular disease. Statins are drugs used for preventing and treating atherosclerosis that causes chest pain, heart attacks, strokes, and intermittent claudication in individuals who have or are at risk for atherosclerosis..

Statins also increase HDL ("good") cholesterol. The dose range for is 5-80 mg/day given preferably in the evening. Lowering LDL cholesterol levels slows and may even reverse coronary artery disease. 1 2 3 Next simvastatin Index Glossary Report Problems to the Food and Drug Administration You are encouraged to report negative side effects of prescription drugs to the FDA.